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EOLO.

Redefining Gastrointestinal Diagnostics

The Breath Analyzer.

CliniChrom has developed an instrument that fully automates all pre-analytical treatment steps, sample injection, and analysis. It processes over 1,440 tubes per day—equivalent to approximately 180 patients per day—significantly boosting operational efficiency.


In less than a minute, EOLO delivers concentration levels of hydrogen, methane and carbon dioxide (control analyte), with the option to additionally measure hydrogen sulfide. Results can be printed, exported as CSV files, or transmitted directly to a Laboratory Information Management System (LIMS), streamlining data management and supporting faster, more informed clinical decisions.


The system is fully customizable to meet your specific requirements, further optimizing laboratory workflows and productivity.


This approach ensures maximum resource utilization, reduced turnaround times, and a significant improvement in both the efficiency and accuracy of analytical results.​

EOLO - The revolutionary all-in-one analyzer for Carbohydrate Intolerances, SIBO and H. pylori

EOLO by CLINICHROM is a fully automated, integrated platform for diagnosing carbohydrate intolerances, SIBO, and H. pylori infections. 

This state-of-the-art system streamlines laboratory workflows—from sample injection to LIMS reporting—by analyzing breath samples collected after the ingestion of specific sugar substrates or a ¹³C-labeled urea solution. 

It provides clinical laboratories with a highly efficient and powerful tool for the diagnosis of digestive disorders.

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Why does a patient need a breath test ?

Lactobacillus, Normal Flora Of Small Intestine

Breath tests are used to evaluate how effectively the body digests and absorbs certain sugars. Some individuals have difficulty absorbing carbohydrates such as lactose or fructose. When this occurs, undigested sugars are fermented by gut bacteria, producing gases like hydrogen, methane and hydrogen sulfide, which are then detected in exhaled brea​th.


Elevated gas levels indicate carbohydrate malabsorption, bacterial overgrowth or bacterial infection, supporting the diagnosis of gastrointestinal conditions such as lactose intolerance, fructose malabsorption, small intestinal bacterial overgrowth (SIBO) or H. pylori infection.

Breath testing is commonly used to diagnose:

  • Carbohydrate Intolerance / Malabsortion
    • Lactose intolerance
    • Fructose malabsortion
    • Sorbitol malabsortion
  • SIBO (Small Intestinal Bacterial Overgrowth)
  • Helicobacter Pylori infection.


What does the test involve ?

Preparation

1. Preparation

Some preparation is required before the test. This preparation involves discontinuing certain medications and fasting. Prior to taking the sample, the patient must drink a high-sugar solution.

Digestion

2. Digestion

If a person has a sugar intolerance, the sugar isn't fully absorbed in the small intestine and passes into the large intestine. There, gut bacteria ferment it, leading to increased production of gases like hydrogen, methane, and sometimes hydrogen sulfide.

Sampling

3. Sampling

After drinking the solution, the patient exhales into a tube using a straw to measure gas levels. This process must be repeated at regular intervals over the next three hours to monitor changes in gas production.

Analysis

4. Analysis

The lab technician simply reads the 1D/2D barcodes, loads the labeled tubes into the carousel and starts the sequence. The robot injects the sample into the MicroGC, which reports hydrogen, methane, and carbon dioxide levels in under 2 minutes.

The most accurate non-invasive diagnostic method for Heliobacter pylori​.

Helicobacter pylori is a bacterium associated with gastritis, peptic ulcers and gastric cancer

The EOLO system is capable of performing the ¹³C urea breath test (¹³C-UBT) for the detection of Helicobacter pylori. 

In this test, the patient ingests a urea solution labeled with ¹³C. If H. pylori is present, the bacterium metabolizes the urea, producing labeled ¹³CO₂, which is subsequently detected in the exhaled breath.

The analysis is based on the ¹³C/¹²C isotopic ratio, measured by mass spectrometry. This method is non-invasive, fast, and highly accurate, eliminating the need for an endoscopy.

The H. pylori urea breath test is the most accurate non-invasive diagnostic method.


Don't miss a thing with  H₂S detection.

By incorporating hydrogen sulfide (H₂S) analysis, EOLO detects alternative fermentation pathways missed by standard hydrogen and methane breath analyzers. 

This is crucial for low-hydrogen producers, where sulfate-reducing bacteria rapidly convert hydrogen into H₂S, a process that otherwise leads to false negatives. 

Consequently, measuring H₂S significantly enhances diagnostic sensitivity for SIBO and carbohydrate malabsorption. By delivering a comprehensive profile of intestinal gases, EOLO reduces diagnostic uncertainty and provides healthcare professionals with robust, high-throughput, and precise results for gastrointestinal disorders.

EOLO Advantages

Discover what makes EOLO unique

Laboratory equipment
Fully Automated Workflow

Fully Automated Workflow

EOLO optimizes laboratory workflows by minimizing manual intervention and offering maximum flexibility in sample loading. Additionally, system calibration and verification procedures are fully automated through software.

Fast analysis
Capacity and Performance Flexibility

Capacity and Performance Flexibility

This highly configurable system accommodates 360 to 936 breath sampling tubes and analyzes each sample in under a minute, processing up to 180 patients daily with a dual-analyzer configuration.

Sample tubes
High Resolution and Analytical Precision

High Resolution and Analytical Precision

EOLO ensures accurate clinical diagnoses by delivering highly reliable, precise, and reproducible results with an exceptional correlation coefficient (R² > 0.999) across its entire calibration range. Additionally, the system achieves excellent analytical precision by demonstrating one of the lowest relative standard deviations on the market, with an RSD < 2.5% for H₂, CH₄, CO₂, and H₂S.

H. Pylori Testing
Commercial Options Tailored to Your Needs

Commercial Options Tailored to Your Needs

We offer flexible financing plans, including leasing or rent-to-own models, alongside per-test pricing options to best suit your budget and workflow. Additionally, complete accessories, sampling kits, and breath tubes are readily available.

Tailor-made for you.


H2, CH4 & CO2

Analysis speed with 1 analyzer: 
+750 tubes / day (1.9 min / tube)
Analysis speed with 2 analyzers:
+1400 tubes / day (<1 min / tube)
  • Capacity: up to 720 12 ml Exetainer® tubes
  • Calibration: Manual or Automatic
  • LIMS connection: Available on demand
  • Dimensions (W x D x H): 190mm x 80 mm x 80mm
  • This test is carried out to check whether the patient can properly absorb a specific sugar, in some cases the body is unable to digest sugars like a lactose, fructose or sorbitol.


H2, CH4, CO2 & H2S

Analysis speed with 1 analyzer: 
+750 tubes / day (1.9 min / tube)
Analysis speed with 2 analyzers:
+1400 tubes / day (<1 min / tube)
  • Capacity: up to 720 12 ml Exetainer® tubes
  • Calibration: Manual or Automatic
  • LIMS connection: Available on demand
  • Dimensions (W x D x H): 190mm x 80 mm x 80mm
  • The analysis of H2S it’s important for the intestinal microbiota study in applications like the precise evolution of small intestinal bacterial overgrowth (SIBO).


We work closely with our clients to understand their specific requirements and provide the customized product that best fits their needs.

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Detection Range​

Hydrogen:

5 ppm — 200 ppm

Carbon Dioxide:

1,5% — 7,0 % 

Methane:

5 ppm — 50 ppm

Hydrogen Sulfide:

10-1000 ppb

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