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EOLO.

Redefining Gastrointestinal Diagnostics


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EOLO - The revolutionary all-in-one analyzer for Carbohydrate Intolerances, SIBO and H. pylori


EOLO by CLINICHROM is a fully automated, integrated platform for diagnosing carbohydrate intolerances, SIBO, and H. pylori infections. 

This state-of-the-art system streamlines laboratory workflows—from sample injection to LIMS reporting—by analyzing breath samples collected after the ingestion of specific sugar substrates or a ¹³C-labeled urea solution. 

It provides clinical laboratories with a highly efficient and powerful tool for the diagnosis of digestive disorders.


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Why does a patient need a breath test ?


Lactobacillus, Normal Flora Of Small Intestine


Breath tests are used to evaluate how effectively the body digests and absorbs certain sugars. Some individuals have difficulty absorbing carbohydrates such as lactose or fructose. When this occurs, undigested sugars are fermented by gut bacteria, producing gases like hydrogen, methane and hydrogen sulfide, which are then detected in exhaled breath.


Elevated gas levels indicate carbohydrate malabsorptionbacterial overgrowth or bacterial infection, supporting the diagnosis of gastrointestinal conditions such as lactose intolerance, fructose malabsorption, small intestinal bacterial overgrowth (SIBO) or H. pylori infection.

Breath testing is commonly used to diagnose:

  • Carbohydrate Intolerance / Malabsortion
    • Lactose intolerance
    • Fructose malabsortion
    • Sorbitol malabsortion
    • Laculose malabsortion
  • SIBO (Small Intestinal Bacterial Overgrowth)
  • Helicobacter pylori infection.


What does the test involve ?

Preparation

1. Preparación

Se requiere cierta preparación antes de la prueba. Esta preparación implica suspender ciertos medicamentos y estar en ayunas. Antes de tomar la muestra, el paciente debe beber una solución rica en azúcar.

1. Preparation

Some preparation is required before the test. This preparation involves discontinuing certain medications and fasting. Prior to taking the sample, the patient must drink a high-sugar solution.

Digestion

2. Digestión

Si una persona tiene intolerancia al azúcar, este no se absorbe por completo en el intestino delgado y pasa al intestino grueso. Allí, las bacterias intestinales lo fermentan, lo que provoca una mayor producción de gases como hidrógeno, metano y, a veces, sulfuro de hidrógeno.

2. Digestion

If a person has a sugar intolerance, the sugar isn't fully absorbed in the small intestine and passes into the large intestine. There, gut bacteria ferment it, leading to increased production of gases like hydrogen, methane, and sometimes hydrogen sulfide.

Sampling

3. Toma de muestras

Después de beber la solución, el paciente exhala en un tubo utilizando una pajita para medir los niveles de gas. Este proceso debe repetirse a intervalos regulares durante las siguientes tres horas para controlar los cambios en la producción de gases.

3. Sampling

After drinking the solution, the patient exhales into a tube using a straw to measure gas levels. This process must be repeated at regular intervals over the next three hours to monitor changes in gas production.

Analysis

4. Análisis

El técnico de laboratorio simplemente lee los códigos de barras 1D/2D, carga los tubos etiquetados en el carrusel e inicia la secuencia. El robot inyecta la muestra en el MicroGC, que reporta los niveles de hidrógeno, metano y dióxido de carbono en menos de 2 minutos.

4. Analysis

The lab technician simply reads the 1D/2D barcodes, loads the labeled tubes into the carousel and starts the sequence. The robot injects the sample into the MicroGC, which reports hydrogen, methane, and carbon dioxide levels in under 2 minutes.

Don't miss a thing with  H₂S detection.


By incorporating hydrogen sulfide (H₂S) analysis, EOLO detects alternative fermentation pathways missed by standard hydrogen and methane breath analyzers. 

This is crucial for low-hydrogen producers, where sulfate-reducing bacteria rapidly convert hydrogen into H₂S, a process that otherwise leads to false negatives. 

Consequently, measuring H₂S significantly enhances diagnostic sensitivity for SIBO and carbohydrate malabsorption. By delivering a comprehensive profile of intestinal gases, EOLO reduces diagnostic uncertainty and provides healthcare professionals with robust, high-throughput, and precise results for gastrointestinal disorders.

The most accurate non-invasive diagnostic method for Heliobacter pylori​.

Helicobacter pylori is a bacterium associated with gastritis, peptic ulcers and gastric cancer

The EOLO system is capable of performing the ¹³C urea breath test (¹³C-UBT) for the detection of Helicobacter pylori

In this test, the patient ingests a urea solution labeled with ¹³C. If H. pylori is present, the bacterium metabolizes the urea, producing labeled ¹³CO₂, which is subsequently detected in the exhaled breath.

The analysis is based on the ¹³C/¹²C isotopic ratio, measured by mass spectrometry. This method is non-invasive, fast, and highly accurate, eliminating the need for an endoscopy.

The H. pylori urea breath test is the most accurate non-invasive diagnostic method.



EOLO Advantages.

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Màquina Clinichrom
Icona An automatic barcode scanner can be mounted on demand. Se puede montar un escáner automático de códigos de barras bajo demanda.
Icona Tray capacity ranges from 432 to 936 CLINICHROM tubes.
*Image: 936 tubes option
La capacidad de la bandeja varía de 432 a 936 tubos CLINICHROM.
*Imagen: opción de 936 tubos
Icona We offer different types of tubes and different cap colors. Ofrecemos diferentes tipos de tubos y diferentes colores de tapón.
x2 Single or Double analyzer set up, lowering the analysis time under 1 minute per tube. Configuración de analizador único o doble, reduciendo el tiempo de análisis a menos de 1 minuto por tubo.
Icona Choose between EOLO GC (intolerances), EOLO MSD (H. pylori), or both. Elija entre EOLO GC (intolerancias), EOLO MSD (H. pylori) o ambos.

Learn more about EOLO today.

Detection Range​

Hydrogen:

5 ppm — 200 ppm

Carbon Dioxide:

1,5% — 7,0 % 

Methane:

5 ppm — 50 ppm

Hydrogen Sulfide:

10-1000 ppb