Atypical Neuroleptics In Plasma / Serum

The drugs olanzapine, clozapine, quetiapine, risperidone, and paliperidone (= 9-OH-risperidone) belong to the class of the so called ”atypical” neuroleptics and are used for the treatment of schizophrenia. Co-medication, smoking, caffeine and food are factors that extensively influence their metabolism and thus lead to a high intra- and interindividual variability of drug concentrations in blood. In order to avoid severe side effects by overdosing and to ensure an optimal therapeutic effect, therapeutic drug monitoring (TDM) is required.

The RECIPE Complete Kit represents a fully automated, robust on-line SPE technique, which allows a direct sample injection into the HPLC system.